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We describe a family with parental consanguinity and five to 10 siblings affected by late-onset autoimmune myasthenic gravis.We propose a genetic mechanism as a predisposing factor in this family.Our analysis excludes the major histocompatibility complex,the B subunit of the acetylcholine receptor,and the T-cell receptor x and B subunits as candidate genes for the disorder in this family. |
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